מפורסם
Jonathan Huppert, and, , Weiss, Michal , Kivity, Yogev , ו Huppert, Jonathan D.. מפורסם.
“How Does The Therapeutic Alliance Develop Throughout Cognitive Behavioral Therapy For Panic Disorder? Sawtooth Patterns, Sudden Gains, And Stabilization.”. Psychotherapy Research, 24, 3, Pp. 407 - 418. .
Publisher's Version תקציר Objective: There has been little research on the development of the therapeutic alliance in cognitive behavioral therapy (CBT). This study aims to examine the development of therapeutic alliance in CBT for panic disorder. Method: Nineteen patients were treated with CBT for panic disorder. Pre- and post-session data of the therapeutic alliance and panic symptoms and cognitions were collected. Results: Several patterns were observed, including a sawtooth pattern (within-session improvements followed by decline between sessions; 63% of the patients), sudden gains in the alliance (58%), and late stabilization (89%). The sawtooth pattern was related to less symptom reduction between sessions (explained variance = 20-48%). Though not statistically significant, there were moderate effect sizes for the relationships between outcomes and early alliance and sudden gains (explained variance = 13-17%). Conclusions: Overall, results suggest that intensive data collection is likely to yield underst
Dianne Chambless, Huppert, Jonathan , and, , and, , Siev, Jedidiah , Chambless, Dianne L. , ו Huppert, Jonathan D.. מפורסם.
“Moral Thought-Action Fusion And Ocd Symptoms: The Moderating Role Of Religious Affiliation.”. Journal Of Anxiety Disorders, 24, 3, Pp. 309 - 312. .
Publisher's Version תקציר The empirical literature on the relationship between moral thought-action fusion (TAF) and obsessive-compulsive disorder (OCD) is characterized by mixed findings. Previous studies have reported religious group differences in moral TAF and the relationship between moral TAF and religiosity. In light of those studies and considering the apparent role of moral TAF in scrupulosity, the purpose of this investigation was to evaluate the possible role of religion as a moderator of the relationship between moral TAF and OCD symptoms. The results revealed that (a) Christians endorsed higher levels of moral TAF than did Jews independent of OCD symptoms; (b) religiosity was correlated with moral TAF in Christians but not in Jews, suggesting that Christian religious adherence is related to beliefs about the moral import of thoughts; and (c) moral TAF was related to OCD symptoms only in Jews. That is, for Christians, moral TAF was related to religiosity but not OCD symptoms, and for Jews, moral TA
Dianne Chambless, Huppert, Jonathan , and, , and, , Siev, Jedidiah , Chambless, Dianne L. , ו Huppert, Jonathan D.. מפורסם.
“Obsessive-Compulsive Disorder Is Associated With Less Of A Distinction Between Specific Acts Of Omission And Commission.”. Journal Of Anxiety Disorders, 24, 8, Pp. 893 - 899. .
Publisher's Version תקציר Individuals with obsessive-compulsive disorder (OCD) seem to judge harm caused actively and passively as morally equivalent. In contrast, people generally choose harm by omission over harm by commission, a propensity known as omission bias. Two studies examined the hypothesis that OCD is associated with less omission bias. In Study 1, with a student population, symptoms of OCD and related cognitions were negatively associated with omission bias about washing and checking scenarios targeting common OCD fears. In contrast, neither symptoms nor cognitions related to OCD were associated with general omission bias. In Study 2, individuals with self-reported OCD evinced less omission bias about washing and checking scenarios than did individuals without OCD. Again, general omission bias was not related to OCD. These results support the idea that individuals with elevated OCD symptoms distinguish less than others between acts of omission and commission for harm relevant to general OCD concer
Jonathan Huppert, Foa, Edna B. , Nacasch, Nitzah , Tzur, Dana , Fostick, Leah , Dinstein, Yula , Polliack, Michael , Zohar, Joseph , ו Huppert, Jonathan D.. מפורסם.
“Prolonged Exposure Therapy For Combat- And Terror-Related Posttraumatic Stress Disorder: A Randomized Control Comparison With Treatment As Usual.”. Journal Of Clinical Psychiatry, 72, 9, Pp. 1174 - 1180. .
Publisher's Version תקציר Objective: Empirically based studies have demonstrated that prolonged exposure therapy effectively reduces posttraumatic stress disorder (PTSD) symptoms in a vast range of traumas, yet reports of the efficacy of such therapies in combat- and terror-related PTSD are scarce. In this article, we examine the efficacy of prolonged exposure therapy in combat- and terror-related PTSD in comparison to treatment as usual (TAU). Method: Between July 2002 and October 2005, 30 patients of a trauma unit within a psychiatric outpatient clinic were recruited and randomized into prolonged exposure versus TAU therapies. Patients were diagnosed with chronic PTSD (Mini-International Neuropsychiatric Interview criteria) related to combat- (n=19) or terror-related (n=11) trauma. Main outcome measures included symptoms of PTSD and depression, as measured by the PTSD Symptom Scale-Interview Version and the Beck Depression Inventory. Results: Posttraumatic stress disorder symptom severity was significantly l
Morris Zelkha, Ben-Yehuda, Mordechai , Hartal, Dov , Raveh, Yigal , ו Garti, Nissim.. מפורסם.
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תקציר Disclosed is a process for the manuf. of tomato products, comprises the steps of: (a) pretreating the tomatoes by conventional operations, including crushing; (b) subjecting them to heat treatment; (c) sepg. the crushed tomatoes into serum and pulp contg. at least 500 ppm of lycopene; (d) subjecting the pulp to solvent extn., in order to ext. therefrom an oleoresin contg. lycopene; (e) sepg. the spent pulp; and (f) sepg. the lycopene ext. from the solvents, whereby to obtain oleoresin contg. the lycopene and to recover the solvents. [on SciFinder(R)]
Research on deficits in emotion regulation has devoted considerable attention to emotion-regulation strategies. We propose that deficits in emotion regulation may also be related to emotion-regulation goals. We tested this possibility by assessing the direction in which depressed people chose to regulate their emotions (i.e., toward happiness, toward sadness). In three studies, clinically depressed participants were more likely than nondepressed participants to use emotion-regulation strategies in a direction that was likely to maintain or increase their level of sadness. This pattern was found when using the regulation strategies of situation selection (Studies 1 and 2) and cognitive reappraisal (Study 3). The findings demonstrate that maladaptive emotion regulation may be linked not only to the means people use to regulate their emotions, but also to the ends toward which those means are directed.
The earliest descriptions of obsessive-compulsive disorder (OCD) were religious, as was the understanding of their origins. With the emancipation, religion in OCD was relegated to its status today: a less common symptom of OCD in most Western societies known as scrupulosity. The frequency of scrupulosity in OCD varies in the literature from 0% to 93% of cases, and this variability seems predicated on the importance of religious belief and observance in the community examined. Despite the similarities between religious ritual and compulsions, the evidence to date that religion increases the risk of the development of OCD is scarce. Scrupulosity is presented as a classic version of OCD, with obsessions and compulsions, distress, and diminished functioning similar to those of other forms of OCD. The differentiation between normal religiosity and scrupulosity is presented, and the unique aspects of cognitive-behavioral therapy in treating scrupulosity, especially in religious populations
Whereas some theories of cognitive behavioral therapies (CBT) propose that acceptance and reappraisal conflict with one another, we propose that one component of acceptance, self-acceptance of negative emotions (being nonjudgmental of oneself for experiencing negative emotions), and reappraisal may facilitate one another. We hypothesized that emotion regulation (self-efficacy and frequency of suppression and reappraisal) would be associated with a stronger correlation between self-acceptance and more positive/less negative affect. We also examined whether self-acceptance is associated with a stronger correlation between emotion regulation and affect. Participants (n = 267) completed measures of self-acceptance, affect, and emotion regulation. Use of emotion regulation strategies was associated with stronger relationships between self-acceptance and affect, and self-acceptance was associated with stronger relationships between emotion regulation and affect. This suggests that self-acce
Monnica Williams, Powers, Mark , Huppert, Jonathan , Foa, Edna B. , Franklin, Martin , Hahn, Chang-Gyu , Hembree, Elizabeth A. , Huppert, Jonathan D. , Simpson, Helen Blair , Liebowitz, Michael R. , Campeas, Raphael , Vermes, Donna , Powers, Mark B. , Rosenfield, David , Cahill, Shawn P. , ו Williams, Monnica T.. מפורסם.
“Six-Month Follow-Up Of A Randomized Controlled Trial Augmenting Serotonin Reuptake Inhibitor Treatment With Exposure And Ritual Prevention For Obsessive-Compulsive Disorder.”. Journal Of Clinical Psychiatry, 74, 5, Pp. 464 - 469. .
Publisher's Version תקציר {Objective: This article describes the long-term effects of augmenting serotonin reuptake inhibitors (SRIs) with exposure and ritual prevention or stress management training in patients with DSM-IV obsessive-compulsive disorder (OCD). Method: Between November 2000 and November 2006, 111 OCD patients from 2 academic outpatient centers with partial SRI response were randomized to the addition of exposure and ritual prevention or stress management training, delivered twice weekly for 8 weeks (acute phase); 108 began treatment. Responders (38 of 52 in the exposure and ritual prevention condition, 11 of 52 in the stress management training condition) entered a 24-week maintenance phase. The Yale-Brown Obsessive Compulsive Scale (YBOCS) was the primary outcome measure. Results: After 24 weeks, patients randomized to and receiving exposure and ritual prevention versus stress management training had significantly better outcomes (mean YBOCS scores of 14.69 and 21.37, respectively; t=2.88
Carolyn Rodriguez, Williams, Monnica , Foa, Edna B. , Huppert, Jonathan D. , McLean, Carmen P. , Hahn, Chang-Gyu , Imms, Patricia , Simpson, Helen Blair , Bender, James, Jr. , Maher, Michael J. , Campeas, Raphael , Pinto, Anthony , Rodriguez, Carolyn I. , Van Meter, Page E. , Vermes, Donna , Liebowitz, Michael R. , Rosenfield, David , Powers, Mark B. , Cahill, Shawn P. , ו Williams, Monnica T.. מפורסם.
“Six-Month Outcomes From A Randomized Trial Augmenting Serotonin Reuptake Inhibitors With Exposure And Response Prevention Or Risperidone In Adults With Obsessive-Compulsive Disorder.”. Journal Of Clinical Psychiatry, 76, 4, Pp. 440 - 446. .
Publisher's Version תקציר {Objective: To compare outcomes after 6-month maintenance treatment of adults diagnosed with obsessive-compulsive disorder (OCD) based on DSM-IV criteria who responded to acute treatment with serotonin reuptake inhibitors (SRIs) augmented by exposure and response prevention (EX/RP) or risperidone. Method: A randomized trial was conducted at 2 academic sites from January 2007 through December 2012. In the acute phase, 100 patients on therapeutic SRI dose with at least moderate OCD severity were randomized to 8 weeks of EX/RP, risperidone, or pill placebo. Responders entered the 6-month maintenance phase, continuing the augmentation strategy they received acutely (n = 30 EX/RP
Obsessive-compulsive disorder (OCD) is a relatively common psychiatric disorder characterized by recurrent obsessive thoughts and/or compulsive behaviors. It has been shown that OCD patients suffer from deficits in executive control. During Stroop task performance, it was found that cognitive control in healthy participants adjusts adaptively - control is reduced when conflict is less likely. Twenty-four individuals meeting criteria for OCD and 27 controls carried out two blocks of a Stroop task; one with high control (a third of the trials were neutral) and one with low control (75% of the trials were neutral). In the healthy control group, results replicated previous findings showing increased interference and decreased facilitation in the low control condition compared to the high control condition. OCD participants, on the other hand, showed no difference in results between the two blocks. Moreover, in the high control condition, interference was larger and facilitation was smalle
AVISHAI HENIK, Avnit, A. , Kalanthroff, E. , Ganor, N. , ו Henik, A.. מפורסם.
“Anxiety Modulates The Effect Of Negative Prime-Valance On Visuo-Spatial Information Processing.”. Journal Of Molecular Neuroscience, 53, Pp. S9. .
Publisher's Version Carolyn I. Rodriguez, Zwerling, Jordana , Mahnke, Amanda , Lapidus, Kyle A. B. , Levinson, Amanda , Steinman, Shari A. , Kalanthroff, Eyal , ו Simpson, Helen Blair . מפורסם.
“Challenges In Testing Intranasal Ketamine In Obsessive-Compulsive Disorder.”. Journal Of Clinical Psychiatry, 78, 4, Pp. 466 - 467. .
Publisher's Version AVISHAI HENIK, Gabay, Shai , Gronau, Nurit , Kalanthroff, Eyal , ו HENIK, AVISHAI . מפורסם.
“Conceptual Size Representation In Ventral Visual Cortex.”. Neuropsychologia, 81, Pp. 198 - 206. .
Publisher's Version תקציר Recent findings suggest that visual objects may be mapped along the ventral occipitotemporal cortex according to their real-world size (Konkle and Oliva, 2012). It has been argued that such mapping does not reflect an abstract, conceptual size representation, but rather the visual or functional properties associated with small versus big real-world objects. To determine whether a more abstract conceptual size representation may affect visual cortical activation we used meaningless geometrical shapes, devoid of semantic or functional associations, which were associated with specific size representations by virtue of extensive training. Following training, participants underwent functional magnetic resonance imaging (fMRI) scanning while performing a conceptual size comparison task on the geometrical shapes. In addition, a size comparison task was conducted for numeral digits denoting small and big numbers. A region-of-interest analysis revealed larger blood oxygenation level dependent
AVISHAI HENIK, and, , Linkovski, O. , Kalanthroff, E. , Henik, A. , ו Anholt, G.. מפורסם.
“Did I Turn Off The Stove? Good Inhibitory Control Can Protect From Influences Of Repeated Checking.”. Journal Of Behavior Therapy And Experimental Psychiatry, 44, 1, Pp. 30 - 36. .
Publisher's Version תקציר Background and objectives: Obsessive-compulsive disorder (OCD) is an anxiety disorder characterized by compulsions aimed at reducing anxiety associated with intrusive cognitions. However, compulsive behaviors such as repeated checking were found to increase rather than decrease uncertainty related to obsessive thoughts (e.g., whether the gas stove was turned off). Some recent studies illustrate that OCD patients and their family members have inhibitory deficits, often demonstrated by the stop-signal task. The current study aims to investigate relations between inhibitory control and effects of repeated checking. Methods: Fifty-five healthy participants carried out a stop-signal task followed by a repeated-checking task. Additionally, participants were asked to complete self-report questionnaires measuring OCD, anxiety and depression symptoms. Results: Confirming our hypothesis, participants with poor inhibitory capabilities demonstrated greater uncertainty and memory distrust as a con
Carolyn Rodriguez, Zwerling, Jordana , Shen, Hanyang , Filippou, Maria , Jo, Booil , Kalanthroff, Eyal , Blair Simpson, H. , Burch, Ronald , ו Moskal, Joseph . מפורסם.
“Effect Of A Novel Nmda Receptor Modulator, Rapastinel (Formerly Glyx-13) In Ocd: Proof-Of-Concept.”. Biological Psychiatry, 81, 10, Pp. S345 - S346. .
Publisher's Version